منابع مشابه
Membrane estrogen receptors and energy homeostasis.
Editor's Note: These short reviews of a recent paper in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to mimic the journal clubs that exist in your own departments or institutions. For more information on the format and purpose of the Journal Club, please see Review of Qiu et al. The actions of gonadal steroid hormones in the brain produce myriad ph...
متن کاملNature of functional estrogen receptors at the plasma membrane.
Although rapid signaling by estrogen at the plasma membrane is established, it is controversial as to the nature of the receptor protein. Estrogen may bind membrane proteins comparable to classical nuclear estrogen receptors (ERs), but some studies identify nonclassical receptors, such as G protein-coupled receptor (GPR)30. We took several approaches to define membrane-localized estrogen-bindin...
متن کاملPlasma membrane estrogen receptors exist and functions as dimers.
A small pool of estrogen receptors (ERalpha and -beta) localize at the plasma membrane and rapidly signal to affect cellular physiology. Although nuclear ERs function mainly as homodimers, it is unknown whether membrane-localized ER exists or functions with similar requirements. We report that the endogenous ER isoforms at the plasma membrane of breast cancer or endothelial cells exist predomin...
متن کاملFunctional roles of plasma membrane localized estrogen receptors.
A series of emerging data supports the existence and importance of plasma membrane localized estrogen receptors in a variety of cells that are targets for the steroid hormone action. When estradiol (E2) binds to the cell surface protein, the ensuing signal transduction event triggers downstream signaling cascades that contribute to important biological functions. Aside from the classical signal...
متن کاملPalmitoylation of estrogen receptors is essential for neuronal membrane signaling.
In addition to activating nuclear estrogen receptor signaling, 17β-estradiol can also regulate neuronal function via surface membrane receptors. In various brain regions, these actions are mediated by the direct association of estrogen receptors (ERs) activating metabotropic glutamate receptors (mGluRs). These ER/mGluR signaling partners are organized into discrete functional microdomains via c...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 1999
ISSN: 1078-8956,1546-170X
DOI: 10.1038/71075